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The Power of Natural Senolytics: Unleashing the Benefits of Klotho and Eliminating Zombie Cells



Imagine a world where you could eliminate the aging cells in your body, rewinding the clock on your health and vitality. Discover the incredible potential of natural senolytics and unlock the secrets to healthy aging, as we delve into the power of these compounds in eliminating zombie cells and rejuvenating your body from within. Are you ready to unleash the true potential of your health and embrace a vibrant and youthful future? Let's explore the world of natural senolytics together.

 

Senolytics are a class of drugs or compounds that target and eliminate senescent cells in the body[1]. Senescent cells, also known as "zombie cells," are cells that have entered a state of irreversible growth arrest but are still metabolically active[1]. These cells accumulate in various tissues and organs as we age and contribute to the development of age-related diseases and conditions[1].

 

Klotho, on the other hand, is a protein that plays a vital role in regulating the aging process and promoting healthy cellular function[1][2]. It has been found that the removal of senescent cells by senolytics can significantly boost the production of a protective protein called alpha-Klotho[1]. Alpha-Klotho has been linked to various health benefits, including improved tissue regeneration, enhanced cognition, and lifespan extension[2].

 

Research has shown that senolytics developed at institutions like Mayo Clinic have the ability to clear the bloodstream of senescent cells[1]. By targeting and eliminating these zombie cells, senolytics have the potential to mitigate the negative aspects of aging and contribute to multiple disease prevention[1].

 

Overall, senolytics offer a promising approach to addressing the detrimental impact of senescent cells on aging and age-related diseases[1]. The identification and development of natural compounds with senolytic properties provide exciting avenues for promoting healthy aging and enhancing overall well-being[1].


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The purpose of this blog post is to delve into the fascinating realm of natural senolytics and their potential benefits in upregulating Klotho, a protein associated with healthy aging, while eliminating senescent cells, also known as zombie cells. We will explore the impact of these natural compounds in rejuvenating cellular function, promoting tissue regeneration, and potentially extending lifespan. By understanding the power of natural senolytics, we can unlock the secrets to healthy aging and maximize our overall well-being.

 

Senolytics are a class of drugs or compounds that specifically target and eliminate senescent cells in the body. Senescent cells are cells that have entered a state of irreversible growth arrest, often due to DNA damage or stress. Although senescence is a natural process to prevent damaged cells from becoming cancerous, the accumulation of these senescent cells over time can contribute to aging and age-related diseases.

 

The role of senolytics is to selectively identify and eliminate these senescent cells. By doing so, senolytics promote the removal of dysfunctional or harmful cells from the body, allowing for tissue regeneration and a rejuvenation of cellular function. This targeted approach helps to mitigate the negative effects of senescent cells, as they can often secrete harmful substances that cause inflammation and impair normal tissue function.

 

The elimination of senescent cells by senolytics has shown potential benefits in various aspects of health, including delaying age-related diseases, improving tissue function, enhancing cognitive function, and even extending lifespan in animal studies. By targeting and eliminating these zombie cells, senolytics hold promise as a therapeutic approach to promote healthy aging and potentially prevent or treat age-related conditions.

 

Senescent cells play a significant role in the process of aging and the development of age-related diseases. As we age, senescent cells accumulate in various tissues and organs throughout the body[3]. These cells have entered a state of irreversible growth arrest due to factors such as DNA damage or stress[2]. Although this cell cycle arrest helps prevent damaged cells from becoming cancerous, the accumulation of senescent cells can have detrimental effects on tissue function and overall health.

 

Senescent cells secrete a variety of molecules and substances known as the senescence-associated secretory phenotype (SASP), which can have harmful effects on nearby cells and tissues[3]. SASP factors can induce chronic inflammation, disrupt the normal functioning of surrounding cells, impair tissue regeneration, and contribute to the development of age-related diseases[1][4]. The persistent presence of senescent cells and SASP factors not only accelerates the aging process but also increases the susceptibility to conditions such as neurodegenerative diseases, cardiovascular diseases, cancer, and metabolic disorders[1][2][5].

 

By targeting and eliminating senescent cells, senolytics offer a potential strategy to mitigate the negative impact of senescence on aging and age-related diseases[2]. Clearing these zombie cells from the body can promote tissue regeneration, reduce chronic inflammation, and improve overall cellular function[1]. This approach holds promise in delaying the onset of age-related ailments and potentially extending healthy lifespan[1].

 

Senescent cells play a significant role in aging and age-related diseases by impacting tissue function, promoting inflammation, and contributing to the development of various health conditions. Understanding and addressing the accumulation of senescent cells through interventions like senolytics may open new avenues for combating age-related diseases and improving overall health and well-being.


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Unveiling the Power of Klotho and Its Mystical Origin

 

The KLOTHO gene, named after the Greek fate CLOTHO, was first discovered in 1997. The gene encodes a protein called α-Klotho, which is primarily expressed in organs involved in aging and mineral metabolism, such as the kidneys and brain. But what's the origin of the name CLOTHO? Its etymology interestingly traces back to the Greek word "klōthos," meaning "spindle" or "thread," and also to "klōthēr," meaning "spinner."

 

The Klotho gene was named after the one of the three Fates, from Latin Clotho, from Greek Klō thō, literally "," from klō thein "to spin," from “κάλαθος”. Explained by Rosół as from Egyptian krh ̣t “a basket for fruits”. Klotho is the “spinner of sugar-chains”. In the realm of anti-aging research, few discoveries have sparked as much excitement and promise as the Sugar Basket of Klotho.

 

The Sweet Connection - Glycans and the "Sugar Basket"

 

Delving into the intriguing etymology of "klōthos," we discover an unexpected association with sugars. The word "klōthēr," from which "klōthos" is derived, signifies "sugar basket" or "sugar bowl." This intriguing connection leads us to the captivating realm of glycans, also known as sugar chains. lotho is a protein that has gained significant attention in the field of aging research due to its association with various health benefits and anti-aging properties. It is named after the Greek goddess Clotho, who was believed to control the length of life.

 

One of the key roles of Klotho is its involvement in regulating the aging process. Studies have shown that higher levels of Klotho are associated with improved health and lifespan, while lower levels are linked to accelerated aging and age-related diseases[1][2]. Klotho acts as a powerful anti-aging hormone, influencing multiple biological processes throughout the body.

 

One of the most well-known effects of Klotho is its ability to promote proper kidney function. It helps regulate mineral metabolism and prevents the formation of harmful calcium deposits in the kidneys[3]. Additionally, Klotho has been found to have positive effects on the cardiovascular system, such as reducing the risk of heart disease and stroke[4][5]. It promotes the health of blood vessels, inhibits oxidative stress, and protects against inflammation, all of which contribute to maintaining cardiovascular health.

 

Klotho also plays a vital role in brain health and cognition. It supports the growth and maintenance of neurons, enhances synaptic plasticity, and protects against neuroinflammation and neurodegenerative diseases like Alzheimer's disease[6]. Higher levels of Klotho have been associated with improved cognitive function and memory.

 

Moreover, Klotho has been linked to metabolic health. It influences insulin signaling, promotes glucose uptake, and enhances insulin sensitivity, which can help prevent or manage type 2 diabetes[7]. Klotho has also been found to regulate energy balance and protect against obesity-related complications.

 

Given its numerous health benefits, upregulating the expression of Klotho has become a key area of interest in anti-aging research. Natural senolytics have shown promise in upregulating Klotho and promoting its beneficial effects by eliminating senescent cells[8]. By enhancing Klotho levels, we may have the potential to slow down the aging process, improve overall health, and potentially extend lifespan.

 

Klotho is a protein with remarkable anti-aging properties and is associated with a wide range of health benefits. Its influence on kidney function, cardiovascular health, brain function, and metabolic regulation underscores its importance in promoting healthy aging. Understanding how to upregulate Klotho and harnessing its power may hold the key to enhancing our well-being and combating age-related diseases.


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How Natural Senolytics Can Upregulate Klotho

 

Natural senolytics have been found to upregulate Klotho expression in the body through various mechanisms. One possible mechanism is the inhibition of DNA methyltransferase (DNMT), which leads to increased Klotho expression[3]. Agents such as Rhein, found in Rhubarb, Curcumin, and Genistein, found in Soy or “Glycine Max”, all have been observed to inhibit DNMT-induced DNA methylation, resulting in increased Klotho expression[3][4].

 

Additionally, senolytics have been shown to alleviate ER stress and reduce reactive oxygen species (ROS) generation, which can contribute to the upregulation of Klotho[5]. The reduction in ER stress and ROS has been linked to the restoration of Klotho expression.

 

Furthermore, senolytics have the potential to modulate Wnt signaling[5]. Activation of the Wnt signaling pathway is known to suppress Klotho expression, and senolytics may counteract this suppression and lead to increased Klotho levels.


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The Potential Impact of Increased Klotho

 

Increased Klotho levels have been implicated in various aspects of health and may have potential impacts on aging, cognition, cardiovascular health, and more[1][2][3].

In terms of aging, Klotho has been recognized as a key factor in the regulation of aging processes. It has been found to exert its effects through various molecular pathways, including Wnt, HIF, and IGF-1 pathways[1]. Klotho is involved in the regulation of vitamin D and phosphate metabolism, and its dysregulation has been associated with aging and neurodegeneration[1].

 

In relation to cognition, studies have suggested that Klotho may play a role in maintaining brain health. Brain expression of Klotho has been linked to regulation of ion homeostasis, and it has been proposed as a potential therapeutic target for brain aging[2].

 

Additionally, Klotho has been associated with cardiovascular health. It has been shown to have protective effects on the cardiovascular system by promoting endothelial function, reducing inflammation, and inhibiting pathological processes such as vascular calcification[1].

 

Moreover, Klotho has been implicated in other areas of health such as renal function, skeletal muscle health, and physical function[1][3][4]. It has been shown to have therapeutic roles in the pathophysiology of different organs, including the skeletal muscle and kidneys[3]. Circulating Klotho levels have been associated with physical function, and higher levels have been linked to better physical performance[4].


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Removing Zombie Cells with Natural Senolytics

 

Senescent cells are cells that have entered a state of irreversible growth arrest and are no longer able to divide. These cells accumulate in tissues as we age and contribute to the development of various age-related diseases and conditions. Natural senolytics are compounds that have been identified for their potential to selectively eliminate these senescent cells from the body, thereby improving tissue function and overall health.

 

The role of natural senolytics in targeting and eliminating senescent cells is significant. Senolytics work by selectively inducing apoptosis (cell death) in senescent cells while sparing healthy, non-senescent cells. They do so by targeting specific pathways or vulnerabilities that are elevated in senescent cells.

 

One important pathway that is often targeted by natural senolytics is the Bcl-2 family of proteins. These proteins regulate apoptosis, and senescent cells often have elevated levels of anti-apoptotic Bcl-2 family members, which help them evade cell death. Natural senolytics can disrupt this balance by inhibiting these anti-apoptotic proteins, making senescent cells more susceptible to apoptosis[1].

 

Another common target for natural senolytics is the PI3K/Akt/mTOR pathway. This pathway is overactivated in senescent cells and promotes their survival and resistance to cell death. Natural senolytics can inhibit this pathway, selectively inducing apoptosis in senescent cells[2].

 

Moreover, some natural compounds possess senolytic properties through the modulation of other pathways, such as the NF-κB pathway, the NAD+-dependent deacetylase SIRT1, and the FOXO4/p53 interaction[2].

 

By selectively eliminating senescent cells, natural senolytics have the potential to improve tissue function and combat age-related diseases. Studies have shown that senolytic treatment can lead to the restoration of tissue homeostasis, improved organ function, and mitigation of age-related phenotypes in various tissues[3]. Preclinical studies have demonstrated the efficacy of natural senolytics in reducing senescent cell burden and improving health outcomes in animal models[4].

 

Natural senolytics play a crucial role in targeting and eliminating senescent cells in the body. By selectively inducing apoptosis in these cells, natural senolytics have the potential to improve tissue function, attenuate age-related phenotypes, and contribute to overall health and longevity.


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Natural Compounds Known For Their Senolytic Properties

 

Here are some natural compounds or interventions that are known for their senolytic properties:

 

1.     Quercetin: Quercetin is a flavonoid found in Sophora japonica, fruits, vegetables, and herbs. It has been shown to selectively induce apoptosis in senescent cells, promoting their clearance from tissues[1][2].

2.     Fisetin: Fisetin is a flavonoid found in various fruits and vegetables, such as strawberries, apples, and onions. It has been found to have senolytic effects by targeting senescent cells and promoting their apoptosis[3].

3.     Resveratrol: Resveratrol is a natural compound found in Japanese knotweed, grapes, and blueberries among other sources. It has been studied for its potential senolytic effects by promoting the elimination of senescent cells[5].

4.     Curcumin: Curcumin, a compound found in turmeric, has been investigated for its senolytic properties. It has been shown to induce apoptosis in senescent cells and reduce the senescent cell burden[6].

 

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Scientific Evidence Supporting the Effectiveness of Natural Senolytics in Removing Zombie Cells

 

Research conducted in the field of Glycoimmunology has explored the effectiveness of natural senolytics in removing senescent or "zombie" cells1. Pre-clinical studies conducted on mice have shown promising results, indicating that senolytics can eliminate senescent cells, thereby delaying, preventing, or alleviating various age- and senescence-related conditions1.

 

In one study, scientists found that senolytics could eliminate senescent cells and potentially offer new ways of treating age-related chronic diseases through immunotherapy2. Another review highlights the most promising strategies for translating senescence-targeting therapies into clinical practice, emphasizing cellular senescence as a therapeutic target3. Additionally, recent biomedical advancements targeting senescent cells have attracted significant interest in both the scientific and medical communities4.

 

Please find below the sources supporting the effectiveness of natural senolytics:

These scientific studies provide evidence of the potential effectiveness of natural senolytics in removing senescent cells. However, it's important to consult with healthcare professionals or experts in the field for personalized guidance or recommendations for specific health concerns.


Sources:

1.     Georgina M. Ellison-Hughes. "Download .nbib". source  2

2.     Scientists at UC San Francisco. "Scientists Find Mechanism that Eliminates Senescent Cells". source 

3.     Cellular senescence and senolytics: the path to the clinic. "Review." source

4.     Shuling Song, Tamara Tchkonia, Jing Jiang, James L. Kirkland, Yu Sun. "Targeting Senescent Cells for a Healthier Aging: Challenges and Strategies". source

 

The Benefits of Eliminating Zombie Cells

 

Removing senescent cells through natural senolytics has been suggested to offer a wide range of potential benefits in promoting health and longevity. While research is still ongoing in this field, initial findings indicate several positive outcomes associated with the removal of senescent cells. Here are some potential benefits:

 

1.     Delaying Aging Process: Senescent cells accumulate with age, contributing to the aging process. Eliminating these cells may slow down or delay age-related degenerative processes.

2.     Improved Tissue Regeneration: Senescent cells negatively impact tissue regeneration and healing. By removing them, the body may experience improved tissue repair and regenerative capabilities, leading to better overall health.

3.     Reduced Inflammation: Senescent cells can release inflammatory molecules, contributing to chronic inflammation in the body. Eliminating these cells may help reduce inflammation levels and mitigate associated health problems.

4.     Enhanced Organ Function: Senescent cells can impair the proper functioning of organs. Senolytics have the potential to remove these cells and restore organ function, promoting better overall physiological performance.

5.     Prevention of Age-Related Diseases: Accumulation of senescent cells is associated with various age-related diseases, including cardiovascular disease, neurodegenerative disorders, and cancer. Eliminating senescent cells may potentially reduce the risk and progression of these diseases.

6.     Improved Metabolic Health: Senescent cells can disrupt metabolic processes, leading to conditions like insulin resistance and metabolic syndrome. Removing these cells may improve metabolic health markers, such as glucose regulation and insulin sensitivity.

7.     Enhanced Cognitive Function: Senescent cells have been linked to cognitive decline and neurodegenerative diseases, including Alzheimer's and Parkinson's. Clearing senescent cells may help protect and enhance cognitive function.

8.     Increased Longevity: While still being explored, it is speculated that the removal of senescent cells could extend lifespan and promote healthy aging, potentially leading to a longer and healthier life.

 

Removing senescent cells through natural senolytics holds potential improvements in overall health, tissue regeneration, and reduced risk of age-related diseases. While research is still ongoing, early findings suggest several positive outcomes in these areas:


1.     Overall Health:


  • Senescent cells contribute to the aging process and the decline of overall health. By eliminating these cells, there may be a reduction in age-related degenerative processes, leading to improved vitality and well-being.


2.     Tissue Regeneration:


  • Senescent cells negatively impact tissue regeneration and healing. By removing them, the body's ability to repair and regenerate tissues may improve. This could aid in wound healing, recovery from injuries, and overall tissue health.

3.     Reduced Risk of Age-Related Diseases:


  • Accumulation of senescent cells is associated with age-related diseases, including cardiovascular disease, neurodegenerative disorders, and cancer. Eliminating senescent cells may potentially reduce the risk and progression of these diseases, promoting better long-term health.

  • Cardiovascular Health: Senescent cells can contribute to arterial plaque formation and inflammation within blood vessels, leading to cardiovascular disease. Removing these cells may help maintain healthier blood vessels, reducing the risk of heart disease and stroke.

  • Neurodegenerative Disorders: Senescent cells have been found in the brains of individuals with neurodegenerative diseases such as Alzheimer's and Parkinson's. Clearing these cells may help protect against cognitive decline and reduce the risk of developing these disorders.

  • Cancer Prevention: Senescent cells can promote tumor growth and contribute to cancer progression. Eliminating these cells may help reduce the risk of cancer development and slow down its progression.


Research in these areas is ongoing, and more studies are needed to fully understand the impact of removing senescent cells on overall health, tissue regeneration, and age-related disease prevention. However, early findings provide promising insights into the potential benefits of natural senolytics in these areas.

 

Senolytic interventions have shown promise in various studies, demonstrating positive outcomes in several areas:


1.     Brain aging and neurodegenerative diseases:


  • A study published in Nature showed that senolytic therapy alleviated physiological human brain aging. The study found that the removal of senescent cells improved the cognitive function of aged mice[1].

2.     Immunity, aging, and disease:


  • A study published in the National Library of Medicine assessed the senolytic potency of fisetin, a senolytic compound, in primary murine embryonic fibroblasts. The study found that fisetin exhibited senolytic activity, indicating its potential to target senescent cells[2].

3.     Neurodegenerative diseases:


  • A review published in the National Library of Medicine highlighted the potential of senolytic interventions in neurodegenerative diseases. The review discussed the targeting of basic aging mechanisms to improve overall therapeutic outcomes and broader applicability in treating neurodegenerative disorders[3].

4.     Idiopathic Pulmonary Fibrosis (IPF):


  • The first published clinical trial on senolytic interventions focused on patients with IPF. The trial used an intermittent treatment of dasatinib and quercetin and found that it improved lung function and exercise capacity in the participants[4].


Please note that the examples provided here are not exhaustive, and there may be other case studies and research papers available that demonstrate positive outcomes of senolytic interventions.


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Exploring Natural Senolytic Options

 

Here is a comprehensive list of natural senolytic compounds or interventions:

 

1.     Fisetin: Fisetin is a naturally occurring flavonoid found in certain fruits and vegetables, such as strawberries, apples, and onions. It has demonstrated senolytic activity in animal studies by selectively eliminating senescent cells12.

2.     Quercetin: Quercetin is a flavonoid that is abundant in various plant-based foods, including apples, berries, onions, and green tea. Studies have shown that quercetin can induce senescent cell apoptosis and enhance the clearance of senescent cells from tissues34.

3.     Curcumin: Curcumin is the active compound found in turmeric. It has exhibited senolytic properties and can target senescent cells by inducing their apoptosis56.

4.     Resveratrol: Resveratrol is a polyphenol present in grapes, berries, and red wine. It has been found to possess senolytic properties and can remove senescent cells from various tissues78.

5.     Intermittent Fasting: Intermittent fasting is an eating pattern that involves periods of fasting and feeding. It has been suggested to have senolytic effects by promoting autophagy, the cellular self-cleaning process that eliminates damaged and senescent cells12.

 

These natural senolytic compounds and interventions have shown promising results in preclinical studies and some limited clinical trials.


Sources:

1.     Canudas et al., 2020. https://pubmed.ncbi.nlm.nih.gov/33050000/

2.     Youm et al., 2018. https://doi.org/10.1016/j.cmet.2017.12.011

3.     Katsuumi et al., 2020. https://pubmed.ncbi.nlm.nih.gov/32257986/

5.     Zhang et al., 2016. https://doi.org/10.1038/cddis.2016.40

7.     Yun et al., 2018. https://pubmed.ncbi.nlm.nih.gov/29444439/

8.     Kim et al., 2017. https://pubmed.ncbi.nlm.nih.gov/28108205/

9.     Zhang et al., 2014. https://doi.org/10.1038/cddis.2014.134

10.                        Zhu et al., 2020. https://pubmed.ncbi.nlm.nih.gov/32015455/

11.                        Zhu et al., 2015. https://doi.org/10.1093/biomedgerontology/glv057

12.                        Golde et al., 2019. https://doi.org/10.1089/rej.2019.2235

 

In this blog post, we discussed the potential of natural senolytics in upregulating Klotho and eliminating zombie cells. We provided a comprehensive list of natural senolytic compounds and interventions, including fisetin, quercetin, curcumin, resveratrol, and intermittent fasting.

 

The key takeaway from this post is that natural senolytics show promise in enhancing Klotho expression and clearing senescent cells, which may slow down aging and improve healthspan. However, it is important to consult with healthcare professionals or experts before implementing any of these interventions.

 

We encourage readers to explore natural senolytic options and their potential benefits, and to stay updated on anti-aging research and interventions by subscribing to our blog for future updates.


Explores the senolytic properties of Core Manna and Core Synergy ingredients and their potential in promoting healthy aging. The importance of their senolytic properties are vital in maintaining cellular health and mitigating age-related diseases.


The synergistic effects of combining these ingredients in Core Manna and Core Synergy may further enhance your senolytic potential. Their ingredients work together to support cellular health and overall well-being.


The potential benefits of incorporating Core Manna and Core Synergy into one's wellness routine are may promote proactive aging due to their senolytic properties in promoting longevity and preventing age-related diseases.


In conclusion, we encourage you to explore further and consider incorporating Core Manna and Core Synergy into your daily regimen. By harnessing the senolytic properties of these ingregredients, you can proactively support their cellular health and promote healthy aging.

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