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Long COVID, ACE2, and Chronic Fatigue Syndrome: A Closer Look at Viral Aftereffects

In the wake of the global COVID-19 pandemic, the scientific community has been intensely focusing on understanding the long-term consequences of viral infections. Two conditions, in particular, have come under significant scrutiny due to their complex and debilitating nature: Long COVID and Chronic Fatigue Syndrome (CFS), also known as Myalgic Encephalomyelitis (ME/CFS). Surprisingly, research reveals that each of these conditions may be linked to specific molecules — ACE2 in the case of Long COVID and Ribonuclease L (RNase L) in Chronic Fatigue Syndrome. This blog explores the similarities these conditions share, shedding light on how viral infections can lead to chronic health issues.

Long COVID, Post Viral Fatigue Syndrome and ME/CFS


Long COVID and ACE2


Long COVID, or Post-Acute Sequelae SARS-CoV-2 infection (PASC), refers to a set of symptoms that continue for months beyond the initial COVID-19 infection. Symptoms often include fatigue, breathlessness, headache, and cognitive dysfunction, often referred to as "brain fog." Emerging studies suggest that the interaction between the SARS-CoV-2 virus and the angiotensin-converting enzyme 2 (ACE2) may play a crucial role in the development of Long COVID.


ACE2 is a protein on the surface of many cell types and is involved in heart function, blood pressure regulation, and inflammation. It also serves as the entry point for the coronavirus, which binds to ACE2 to infect cells. During infection, the virus can downregulate ACE2, disrupt its normal functions, and trigger inflammation. This disruption and the ensuing inflammatory responses are believed to contribute to the prolonged symptoms seen in Long COVID.


Chronic Fatigue Syndrome and Ribonuclease L


Chronic Fatigue Syndrome, a long misunderstood condition characterized by extreme fatigue, pain, and cognitive impairments, has been studied for potential viral triggers or immunological abnormalities for years. One of the key findings in many CFS patients is the abnormal activity of a cellular enzyme called Ribonuclease L (RNase L).


RNase L is part of the body’s antiviral pathway and becomes activated when a viral infection is detected. In typical situations, RNase L helps to inhibit viral replication by degrading viral RNA. However, in CFS, research indicates that a dysregulated or overly active RNase L could be contributing to symptoms. A hyperactive RNase L can lead to the degradation of cellular RNA, not just viral RNA, potentially disrupting normal cell functions and contributing to the chronic symptoms of fatigue and malaise seen in CFS patients.


Connecting the Dots: Viral Infections and Chronic Conditions


While Long COVID and CFS are distinct conditions, their potential links to ACE2 and RNase L respectively highlight a fascinating aspect of viral infections — the persistence of symptoms due to altered molecular mechanisms. Both conditions emphasize how infections can extend their impact beyond the acute phase, leading to chronic health issues through interactions with human enzymes and receptors.


The Role of Immune Response


Both conditions also underscore the role of the immune system in post-viral syndromes. An overactive or dysfunctional immune response can lead to a sustained state of inflammation or immune dysregulation, which might maintain or worsen symptoms over time.


Bridging the Challenge: The Intersection of Glycoimmunology in Core Manna and Core Ether Formulations


The cutting-edge realms of glycoimmunology and heart-based science have revealed profound insights into the intricate dance of health, especially in terms of immune system enhancement and cardiovascular health. Both Core Manna and Core Ether stand at the forefront of this revelation, ingeniously incorporating an array of natural compounds recognized for their targeted influence on genes and cellular pathways integral to these health domains. This segment explores how the principles of glycoengineering for enhancing immune response and cutting edge cardiovascular science converge to unlock new potentiations in healthcare.


Glycoimmunology & Cardiovascular Harmony


Glycoimmunology unveils the critical role of glycosylation—the attachment of sugar molecules to proteins or lipids—in immune cell signaling and overall immune system modulation. Meanwhile, the science behind Core Ether dissects the essence of inflammation's impact on the glycocalyx and the ensuing cardiovascular risks. It becomes evident that the glycocalyx, a sugar-heavy coat on the surface of our endothelial cells, is a battlefield where glycoimmunology and cardiovascular health intersect.


The Natural Compound Synergy in Core Manna & Core Ether


Both Core Manna and Core Ether leverage the power of naturally derived compounds such as polysaccharides, mannose, glucosamine, and N-acetylcysteine (NAC) among others, celebrated in research for their roles in targeting genes and pathways critical to glycoimmunology and cardiovascular conditions. These compounds serve manifold purposes:


  • Inflammation Modulation: In the context of cardiovascular wellness, compounds like glucosamine and NAC found in these formulations can help regulate inflammation—a core issue in the degradation of the glycocalyx and subsequent cardiovascular detriment.

  • Immune System Optimization: By enhancing the glycosylation processes and supporting the glycocalyx, these natural compounds boost the immune system's efficiency, crucial for both fending off pathogens and moderating inflammation.

  • Glycan Structure Optimization: Glycoengineering principles underscore the manipulation of glycan structures to bolster immune responses. Core Manna and Core Ether embody this strategy by supplying crucial glycans and co-factors that support optimal glycan assembly and function.


Envisioning the Future of Health


The innovative formulations of Core Manna and Core Ether, rooted in the pioneering science of glycoengineering represent a leap towards a future where immune health and cardiovascular resilience are significantly enhanced. This synergy of natural compounds, targeting both glycoimmunological aspects and the integrity of the cardiovascular system, not only underscores the potential of harnessing nature's bounty in healthcare but also exemplifies the power of integrated scientific approaches in addressing complex health issues.


Exploring Natural Compounds for Long COVID and Chronic Fatigue Syndrome


The ongoing journey to find effective treatments for emerging health conditions such as Long COVID and Chronic Fatigue Syndrome (CFS) has spotlighted the potential of natural compounds. These substances, historically revered in various traditional medicines, are now being recognized for their roles in managing and potentially mitigating the symptoms associated with these persistent conditions. Here, we will delve into specific natural compounds recommended for Long COVID and Chronic Fatigue Syndrome and explore their therapeutic properties.


Natural Compounds for Long COVID

Long COVID, characterized by a cluster of symptoms lingering after recovery from the acute phase of COVID-19, can significantly impair one's quality of life. The following natural compounds have been identified for their potential benefits:


  • NAD+ & Pyruvate: Enhances cellular metabolism and energy production, potentially alleviating fatigue and boosting recovery.

  • Caffeine (Green Bean Coffee Extract) and Ginseng: Known for their energizing effects, helping to combat the profound tiredness associated with Long COVID.

  • Resveratrol/Japanese Knotweed and Quercetin: Exhibit anti-inflammatory properties, potentially reducing systemic inflammation associated with Long COVID.

  • N-Acetylcysteine & Alpha-lipoic Acid: Act as powerful antioxidants, supporting detoxification and protection against oxidative stress.

  • Spirulina & Vitamin K2: Support immune system function, possibly improving resilience against lingering viral effects.

  • Herbal Additions (Tangerine, Cinnamon, Thyme, Ginger, Schisandra): These herbs contribute various health benefits, from improving circulation to enhancing digestive health, all of which can be compromised in Long COVID.

  • Liver Extracts: Known for their high nutrient content that can support overall health and vitality.


Natural Compounds for Chronic Fatigue Syndrome


Chronic Fatigue Syndrome, a complex disorder characterized by extreme fatigue that cannot be explained by any underlying medical condition, may also benefit from natural compounds:


  • Garlic and Hawthorn: These offer cardiovascular support, potentially improving blood flow and energy levels.

  • Benfotiamine and Ashwagandha: Known to boost energy metabolism and adaptogenic properties, respectively, helping the body manage stress.

  • Butyric Acid/Inulin FOS and Tomato/Lycopene: Support gut health and provide antioxidants, respectively, important as gut health and oxidative stress are key considerations in CFS management.

  • Quercetin & Ginseng: Similar to their role in Long COVID, these compounds support energy levels and immune function.

  • Caffeine (Green Bean Coffee Extract): Provides a temporary increase in alertness and can alleviate the pervasive lethargy associated with CFS.


Both Long COVID and Chronic Fatigue Syndrome pose significant challenges to individuals affected by these conditions. Utilizing natural compounds can be a beneficial adjunct to conventional treatment strategies, potentially aiding in symptom management and overall recovery. Both the variety and multi-functional nature of these compounds offer a broad spectrum approach to managing these complex syndromes, making them worthy of consideration in tailored health protocols. As always, individual treatments should be discussed with healthcare providers to customize a plan that considers all aspects of an individual's health profile.


  • Natural Compounds for Long Covid: NAD+, Caffeine (Green Bean Coffee Extract), Tangerine, Cinnamon, Thyme, Ginger, Schisandra, Pyruvate, Pycnogenol, N-Acetylcysteine, Genistein (Glycine Max), Ginseng, Sunflower Lecithin, Resveratrol/Japanese Knotweed, Vitamin K 2, Liver Extracts, Spirulina, Quercetin, Date Palm, Alpha-lipoic Acid.

  • ·Natural Compounds for Chronic Fatigue Syndrome: Garlic, Benfotiamine, Liver Extracts, Hawthorn, Caffeine (Green Bean Coffee Extract), N-Acetylcysteine, Butyric Acid/Inulin FOS, Tomato/Lycopene, Orange, Ginseng, Quercetin, Date Palm, Ashwagandha.

In conclusion, as we delve deeper into the mysteries of glycoimmunology and cardiovascular science, Core Manna and Core Ether stand as beacons of hope, illustrating that through scientific ingenuity and nature's wisdom, achieving a state of profound health is within our grasp. The path forward is illuminated by these formulations, guiding us towards a realm where immune response is empowered, and heart health is safeguarded through the sweet, intricate dance of sugars at the cellular frontier.

Core Ether

Core Manna

Required Disclaimer: This is intended for education and research, These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a healthcare professional before starting any diet, exercise, or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. You are solely responsible for doing your own research on any information provided. This Site should not substitute professional advice. Individual results may vary. Database references herein are not all-inclusive. Getting well from reading or using the information contained herein is purely coincidental. Any and all products or services may be subject to change.

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