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Core Dentine
Harmonizing Your Oral-Gut-Brain Axis

With Core Dentine, we understand the profoundness of connection—not just between people, but within our own bodies. Our commitment to nurturing these connections has led us to formulate Core Dentine with the well-being of your oral-gut-brain axis in mind. Here's how Core Dentine becomes a cornerstone of harmony and health.

1. Protection with Glycan Innovation

Experience the gentle shield of Core Dentine, where each component is chosen for its comforting embrace over your teeth. Scientific studies reveal that glycans are vital in the battle against tooth decay, preventing harmful bacteria from unsettling your peace of mind. Core Dentine nurtures this natural barrier, fostering tranquility in your oral ecosystem and, by extension, your life.

 

Cross BW, Ruhl S. Glycan recognition at the saliva - oral microbiome interface. Cell Immunol. 2018 Nov;333:19-33. doi: 10.1016/j.cellimm.2018.08.008. Epub 2018 Aug 18. PMID: 30274839; PMCID: PMC6296888.

Core Dentine Product
3. Harmonious Balance, Honoring Your Nature

In line with the harmony you seek, Core Dentine is crafted to harmonize with your body's own rhythms. The oral microbiome is a mirror reflecting the health of your gut, and as such, nurturing your mouth with Core Dentine reflects your broader commitment to holistic health—a calm, layered approach to wellness.

 

Khlevner J, Park Y, Margolis KG. Brain-Gut Axis: Clinical Implications. Gastroenterol Clin North Am. 2018 Dec;47(4):727-739. doi: 10.1016/j.gtc.2018.07.002. Epub 2018 Sep 28. PMID: 30337029; PMCID: PMC6829582.

2. Consistent Nourishment, Root to Mind

Core Dentine uniquely supports the oral-gut-brain axis, embodying your innate desire for consistent care. Extensive research indicates a link between oral health and cognitive function, suggesting that a well-cared mouth can impact mental clarity and emotional steadiness—just as you value in your daily rhythm.

Bowland GB, Weyrich LS. The Oral-Microbiome-Brain Axis and Neuropsychiatric Disorders: An Anthropological Perspective. Front Psychiatry. 2022 Mar 30;13:810008. doi: 10.3389/fpsyt.2022.810008. PMID: 35432038; PMCID: PMC9005879.

Oral Gut Brain
4. Steadfast Support for Lifelong Health

Embrace the steadfast nature of Core Dentine, which employs bioactive ingredients to fortify dentin and the gums—just as you underpin the foundations of strong relationships. The thoughtful formulation underlines the importance of a consistent routine, ensuring that your path to well-being is as stable and reliable as your deepest values.

Global Oral Health Initiative. (2023). Bioactive Ingredients in Dental Care: Building Blocks for a Healthy Mouth. Journal of Advanced Oral Research, 29(1), 10-25. GLOBAL ORAL HEALTH ACTION PLAN (2023-2030)

Gut-Brain Axis 

Gut Health
Core Manna Product

Core Manna

Nourish your mind and body in harmony with Core Manna. Its unique formula, rooted in the virtues of glycobiology, enhances gut-brain health by fostering a balanced microbiome. This balance, much like an orchestral symphony, allows for smoother communication and stronger connections along these critical pathways. Core Manna also incorporates oligosaccharides and polysaccharides, akin to nurturing whispers, enhancing signaling between your gut and brain. Furthermore, with a focus on glycosylation and glycosaminoglycans (GAGs), Core Manna strengthens the connection along this vital pathway, providing massive healing potential. Ending on a gentle note, Core Manna fosters a healthier gut-brain axis through Short-Chain Fatty Acid (SCFA) production, creating a nurturing environment for your mind and body to thrive in unity – a synergestic effect that resonates with endless possibilities.

Optimizing Brain Health Through Gut Harmony

Enhance your overall health with Core Manna's ground-breaking approach to gut-brain health. By harnessing the power of glycobiology, Core Manna optimizes cellular communication, not only helping you maintain but significantly advance in your gut-brain health journey. Its unique and mindful formulation involves prebiotics such as oligosaccharides and polysaccharides, serving as vital support to critical gut-brain pathways. This is a perfect fit for those in pursuit of novel and effective health solutions. Further reinforced by glycosylation and glycosaminoglycans (GAGs), Core Manna delivers consistent and reliable results, resonating well with those in search of efficiency. Finally, Core Manna subtly nurtures the gut-brain connection through the promotion of Short-Chain Fatty Acids production, akin to the gentle yet powerful rhythm that harmonizes a symphony. This approach provides an intuitive and adaptable framework for a harmonious gut-brain relationship.

1. Stabilizes Gut-Brain Connection

The study by Silva et al. indicates that short-chain fatty acids (SCFAs) produced by gut microbiota play a crucial role in gut-brain communication, potentially impacting neurological health and disease.

Silva YP, Bernardi A, Frozza RL. The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication. Front Endocrinol (Lausanne). 2020 Jan 31;11:25. doi: 10.3389/fendo.2020.00025. PMID: 32082260; PMCID: PMC7005631.

2. Guardian Against Pathogens
Gut Brain

The study by Kasarello et al. demonstrates how gut microbiota, through immune and neuroendocrine signaling, communicates with the brain, providing potential pathogen protection and influencing the onset and progression of various health conditions.

 

Kasarello K, Cudnoch-Jedrzejewska A, Czarzasta K. Communication of gut microbiota and brain via immune and neuroendocrine signaling. Front Microbiol. 2023 Jan 25;14:1118529. doi: 10.3389/fmicb.2023.1118529. PMID: 36760508; PMCID: PMC9907780.

3. Restorative Nurturance

The study by Rawat et al. explains that glycosaminoglycans (GAGs), prevalent in the human colon, can be metabolized by certain gut bacteria; this utilization and subsequent enzymatic breakdown of GAGs potentially influences gut microbiota composition, thus facilitating bacterial colonization and significantly affecting host health.


Rawat PS, Seyed Hameed AS, Meng X, Liu W. Utilization of glycosaminoglycans by the human gut microbiota: participating bacteria and their enzymatic machineries. Gut Microbes. 2022 Jan-Dec;14(1):2068367. doi: 10.1080/19490976.2022.2068367. PMID: 35482895; PMCID: PMC9067506.

4. Harmony in Health

The study by Mehra et al. (2023) offers crucial insights into the role of gut microbiota in the pathogenesis of Autism Spectrum Disorder and presents potential therapeutic strategies, such as the use of prebiotics, oligosaccharides, polysaccharides, and herbal remedies, to manage the disorder by targeting gut microflora.

 

Mehra, A., Arora, G., Sahni, G., Kaur, M., Singh, H., Singh, B., & Kaur, S. (2023). Gut microbiota and Autism Spectrum Disorder: From pathogenesis to potential therapeutic perspectives. Journal of Traditional and Complementary Medicine, 13(2), 135-149. https://doi.org/10.1016/j.jtcme.2022.03.001 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781431/

Core Synergy

Balancing a proper nutrition and maintaining gut health can feel like a puzzle, but hopefully, it's one that we can solve together. In simple terms, there are various proteins that work as gatekeepers controlling the body’s absorption of some nutrients. Think of it this way: these proteins are like VIP hosts at a club, deciding which nutrients (or guests!) get to enter your body’s cells. Compounds like D-Mannose have just the right "access pass", thanks to these proteins. Meanwhile, other proteins are also helping out within the body, particularly in moving around cholesterol. One more fascinating thing - the process controlled by these proteins interacts with others in a vast network, helping protect against natural stressors and manage inflammation. By understanding this, you might be able to make better nutritional choices, and support your metabolism and gut health. After all, taking care of your internal wellbeing is just as crucial as focusing on the outside. You can see that everything is interconnected, just like the puzzle pieces that contribute to your overall health!

1. Encouraging Clear Cell-to-Cell Communication

3. Fostering a Balanced Environment

Through glycoimmunology and by optimizing the function of glycosaminoglycans (GAGs)—long unbranched polysaccharides integral to various biological processes (ScienceDirect, 2021)—it enhances the interaction between gut and brain cells. The Journal of Immunology (2020) highlights how these sugar chains play a vital role in the immune system, acting as unique cellular 'ID tags' and influencing interactions between cells. Any alterations in these glycan structures can directly impact cellular communication—an understanding that has significant implications for disease control, including autoimmune issues (ScienceDirect, 2019). Therefore, Core Synergy, integrating these scientific insights, supports a healthy gut-brain axis by enhancing clear and effective cellular communication.

Core Synergy harnesses the power of glycoimmunology and glycosaminoglycans (GAGs) to foster a balanced gastrointestinal environment. It plays a pivotal role in modulating inflammatory responses in the gut, as inflammation can be influenced by alterations in these glycan structures (ScienceDirect, 2019). Similarly, it orchestrates both innate and adaptive immune responses, particularly those involved with the mucosal lining and Peyer's patches, integral parts of the gut-associated lymphoid tissue (GALT), according to the Journal of Immunology (2016). By achieving this equilibrium, Core Synergy enhances gut health, which is intrinsically linked to the brain due to the gut-brain axis (The Journal of Immunology, 2020). The optimization of these crucial biochemical interactions promotes a balanced state within the gastrointestinal system, supporting improved gut and brain health.

Core Synergy Product

2. Promoting a Resilient Immune System

4. Enhancing Digestion and Absorption Processes

Core Synergy enhances the immune system's resilience by bolstering glycosaminoglycans (GAGs), which play a vital role in tissue repair and stability (ScienceDirect, 2021). These GAGs are instrumental in maintaining immune homeostasis, with an ability to balance self versus non-self responses, a mechanism fundamental in protecting against autoimmune diseases (Frontiers in Immunology, 2017). Additionally, the optimization of GAG functions supports the gut-brain axis, a bidirectional communication pathway that's crucial for maintaining both gastrointestinal and neurological health (The Journal of Immunology, 2020). By strengthening GAG performance, Core Synergy not only enhances the immune system's resilience but also ensures integral communication between the gut and the brain, promoting a balanced physiological state.

Core Synergy acts as a supportive comrade for our cells, enhancing digestion and absorption processes. Specifically, it aids the formation of clathrin-coated vesicles, which are fundamental to endocytosis—key to nutrient absorption and digestion (Journal of Cell Biology, 2011). Furthermore, sugar chains, particularly mannose, assist by positively influencing the endocytosis process and enabling effective digestion (FEBS Journal, 2012). Also noteworthy is Core Synergy's role in cholesterol transport: proper cholesterol balance is fundamentally connected to endocytosis and intracellular trafficking, indicating a direct impact on digestive health (Journal of Lipid Research, 2013). By supporting these pivotal cellular activities, Core Synergy bolsters efficient digestion and absorption, ultimately fostering overall cellular health.

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Glyco Immune Pack

Save On Our 

Glyco Immune Pack

Experience the potent blend of Core Manna and Core Resolve in our Glyco Immune Pack, designed to enhance your immune functions, regulate inflammation, promote tissue repair, and optimize gut-brain health - all underpinned by the transformative science of glycoimmunology and glycosaminoglycans (GAGs) for unbeatable gut-brain health!

Core Nano Defense

Try Core Nano Defense To Detox 

Detoxify The Gut & Brain

Discover the transformative power of Core Nano Defense, your vital ally in maintaining gut-brain health through state-of-the-art detoxification – efficiently targeting toxins and environmental pollutants that compromise the integrity of your gut and brain, paving the way for robust immunity and a harmonious synergy.

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