Inflammation
Core Resolve
Core Resolve, at the intersection of advanced science and natural relief, leverages the innate healing abilities of the body to tackle inflammation. Its powerful blend of natural ingredients includes Specialized Pro-Resolving Mediators (SPMs), our body’s resolution specialists for inflammation, contributing immensely to tissue repair and homeostasis.
Soothing Inflammation the Natural Way
Discover Core Resolve, a groundbreaking product designed to manage inflammation, specifically crafted to support the imbalanced prolonged hyper-inflammatory cytokine responses and restore tissue homeostasis. At its core are the Specialized Pro-Resolving Mediators (SPMs), a set of natural compounds inherently produced by the body to control and end inflammation.
1. The Inflammation Solution Nature Intended
The Basil & Levy (2016) study highlights the benefits of specialized pro-resolving mediators (SPMs) as endogenous regulators that actively control infection and inflammation, thereby enhancing host defense while preventing excessive inflammation and damage to nearby tissues.
Basil, M., Levy, B. Specialized pro-resolving mediators: endogenous regulators of infection and inflammation. Nat Rev Immunol 16, 51–67 (2016). https://doi.org/10.1038/nri.2015.4
2. A Stabilizer for Immune Response
The study by Pan et al. demonstrates that specialized pro-resolving mediators (SPMs) play a vital role in both limiting the inflammatory response and promoting the resolution of inflammation, thereby maintaining homeostasis, and suggests that these regulators could effectively ameliorate symptoms in several inflammation-related diseases.
Pan, G., Zhang, P., Yang, J., & Wu, Y. (2022). The regulatory effect of specialized pro-resolving mediators on immune cells. Biomedicine & Pharmacotherapy, 156, 113980. https://doi.org/10.1016/j.biopha.2022.113980.
3. Revving the Cellular Engines: Mitochondrial ATP
The Talley and Mohiuddin study reveals how fatty acid oxidation serves as a major energy source particularly during periods of high energy demand and fasting, providing a highly efficient means of energy production that spares muscle tissue from catabolic breakdown, thus contributing to overall health and well-being (Biochemistry, Fatty Acid Oxidation, 2023).
Talley JT, Mohiuddin SS. Biochemistry, Fatty Acid Oxidation. [Updated 2023 Jan 16]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK556002/
4. The Analytically Proven Formula
The study by Kim & Kim (2021) suggests that specialized pro-resolving lipid mediators and their receptors could be a promising therapeutic strategy for managing the cytokine storm in SARS-CoV-2 infections, thereby mitigating severe illness and mortality associated with the virus.
Kim, S., & Kim, H. (2021). Role of specialized pro-resolving lipid mediators and their receptors in virus infection: a promising therapeutic strategy for SARS-CoV-2 cytokine storm. Archives of Pharmacal Research, 44, 84-98. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781431/
Core Synergy
Drawing on the principles of glycoimmunology and supported by scientific research, Core Synergy is meticulously designed to support a balanced inflammatory response. It fosters harmony within the bodily systems by optimizing the functions of Glycosaminoglycans— which play important roles in various physiological and pathological processes including cancer, bacterial and viral infections, inflammation, Alzheimer’s disease, and many more. The serene modulation of the immune inflammatory response is aided by the critical roles of the anti-inflammatory agents, such as Glucosamine, a key GAG component, and Chondroitin sulfate, which help control inflammation. In essence, Core Synergy embodies a synergy between science and nature to ensure a serene, steady, and supportive path to optimal health.
1. Facilitating Cellular Harmony with Glycobiology
3. Serene Immune Modulation with Sugars
Core Synergy harnesses the science of glycobiology to promote equilibrium within the body's immune system. By supporting glycan function—vital for immune cell communication—Core Synergy helps balance inflammatory responses, as explained in the study by Rabinovich et al. (2012), which elucidates the role of glycans in immunological balance and inflammation control ("Glycans in the Immune System and The Altered Glycan Theory of Autoimmunity: A Critical Review," Journal of Autoimmunity).
2. Steadfast Support Through GAGs
Core Synergy gently modulates inflammatory activity through the power of glycans, which have been shown to play critical roles in immune function. Glycans engage in a serene dance of signaling that can help guide the immune system to act appropriately, as depicted in the work of Cummings (2009) on the influence of glycans ("The repertoires of glycan determinants in the human glycome," Molecular BioSystems).
4. Stability in Inflammation Control
Core Synergy's inclusion of various GAGs like Glucosamine—a building block for glycosaminoglycans (GAGs)—reinforces the body's resilience against inflammation. Scientific evidence, such as the findings by Vigerust and Shepherd (2007), shows that GAGs contribute to maintaining the structural integrity of tissues and modulating inflammation ("Virus glycosylation: role in virulence and immune interactions," Trends in Microbiology).
Core Synergy leverages the physiological insights into GAGs and their role in helping manage inflammatory responses. The comprehensive review by Silbert and Sugumaran (2002), which discusses the biological functions of GAGs in detail, underpins this point with evidence ("Biosynthesis of chondroitin/dermatan sulfate," IUBMB life).
